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We investigate how intermediary metabolism shapes brain development, function, and vulnerability to disease. By integrating mass spectrometry, genetics, and systems neuroscience, our work reveals how metabolic disruptions, particularly in inborn errors of metabolism, drive neurodevelopmental and neurodegenerative disorders, and how targeted metabolic interventions can restore brain health.
We develop spatial neurometabolomics approaches that integrate mass spectrometry imaging with stable isotope tracing to map brain metabolism in situ at high resolution. By combining ¹³C tracers with spatial metabolite profiling, we capture both metabolite distributions and metabolic flux to dissect active pathways across brain regions.
We create mathematical models of brain metabolism to quantify metabolic fluxes and substrate utilization across cell types. By integrating NMR and mass spectrometry data with compartment-specific kinetic modeling, our work reveals how glucose, acetate, and other nutrients differentially support central carbon metabolism and connected pathways in brain physiology and disease.
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